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Abnormal metabolic shift by increased aerobic glycolysis (Warburg effect) is a common feature of cancer cells.
This metabolic shift in is required for the rapid cell proliferation, rather than energy production.
We next examined if the miR-155 mediated metabolic shift is also valid in human cancer.
The metabolic shift in this case is the upregulation of glycolysis.
Understanding how cancer cells drive such metabolic shift is crucial to identify potential targets for cancer therapeutics.
Moreover, the induction and decay dynamics of gene expression over time suggest a metabolic shift in primed individuals.
During reprogramming, the reverse metabolic shift from oxidative phosphorylation to glycolysis has been observed.
Next, we examined whether the miR-155 driven metabolic shift also occurs in human breast tumors (Clinical information summarized in Supplementary Table 6).
It is known that mitochondria undergo dynamic changes in structure and function during iPSC generation due to the metabolic shift from oxidative phosphorylation to glycolysis38.
This metabolic shift was clearly induced by a small electron uptake that represented less than 0.6% of the electrons consumed by C. pasteurianum.
Both beneficial effects appear to be driven by a systemic metabolic shift from oxidative phosphorylation towards accelerated and early aerobic glycolysis.
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