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We relied on the CLP model given that it closely mimics many aspects of the inflammatory, hemodynamic and metabolic responses observed in human sepsis originating from the abdominal compartment [1,21].
In the present study we characterize for the first time, the metabolic responses of skeletal muscle, exposed to repeated periods of contraction with low blood flow, using the canine gracilis model [ 18] which reflects the metabolic responses observed in human skeletal muscle under similar circumstances [ 9].
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The purposes of this study were thus the following: (a) to evaluate the reproducibility of 18F- FDG PET/CT for assessing the activity of the disease; (b) to compare metabolic parameters to clinical, biological and ultrasonographic parameters before and after rituximab treatment; (c) to evaluate whether the metabolic response observed at week 16 could predict the outcome two months later (week 24).
Optimal metabolic responses were observed towards IGF-I applied in conjunction with EGF.
However, further studies are required to evaluate the impact of extravasation in situations where less marked metabolic responses are observed or important extravasations occur.
Metabolic responses were observed towards each growth factor when applied to the culture medium, but not towards culture plastic pre-treated with VN and, or growth factors.
Quick metabolic responses were observed during the first 30 s of glucose shortage, and after 70 s, fundamental transcriptional programs were initiated.
Similar metabolic responses were observed for the two chemotherapeutic agents.
This is of clinical relevance since muscle wasting including accelerated protein breakdown and hyperglycemia are metabolic responses frequently observed in critically ill or severely injured patients.
During surveillance, PET/CT was repeated in January 2012 (Figs. 1 and 2), and complete morphologic and metabolic responses were observed, both in the liver and in the retroperitoneum.
The results showed that female mussels were sensitive to BPA (1 and 10 μg/L), whereas no significant metabolic responses were observed in males.
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