Sentence examples for metabolic regulators from inspiring English sources

The identification of differentially regulated, but structurally unidentified, metabolites in untargeted metabolomic analyses remains a major bottleneck for advancement of the field and more comprehensive understanding of cancer metabolism, including metabolic regulators.

SIRT1, as a key mediator of beneficial effects of caloric restriction, regulates lipid and glucose metabolism by deacetylating metabolic regulators, as well as histones, in response to nutritional deprivation.

These results indicate that in addition to the quorum-sensing system regulation, the metabolic regulators may also affect the expression level of Hcp.

Not only did OA inhibit glucose metabolism via two p53-related metabolic regulators, TIGAR and SCO2, but it also induced dissociation of HKII from the mitochondria through SIRT3.

Cumulatively, swertiamarin targets potential metabolic regulators AMPK and PPAR-α, through which it regulates hepatic glycemic burden, fat accumulation, insulin resistance and ROS in hepatic steatosis which emphasizes clinical significance of swertiamarin in regulating metabolism and as a suitable candidate for treating NAFLD.

Three of its dimerization partners from the S1-group bZIP1, S1-group bZIP1IP53—were shown to bZIP11ortand metabZIP53 wereatorshownpecially under energy storvation conditions, and to regulate the expression of ASN1 and ProDH as well (Hanson et al., 2008; Dietrich et al., 2011; Ma et al., 2011).

Recent studies have elucidated new substrates for Sirt1 that are involved in metabolic regulation, and have further delineated Sirt1's functional associations with other metabolic regulators like AMP-activated kinase (AMPK).

Resident adipose tissue immune cells have also been shown to act as local metabolic regulators through the release of factors that alter adipocyte metabolism and differentiation [ 100, 104, 105].

Here we discuss how SIRT1 levels are regulated by microRNAs (miRs) which are emerging as important metabolic regulators; the recently identified nuclear receptor FXR/SHP cascade pathway that controls the expression of miR-34a and its target SIRT1; and a FXR/SIRT1 positive feedback regulatory loop, which is deregulated in metabolic disease states.

Long chain polyunsaturated fatty acids and acyl-CoAs, are metabolic regulators of many transcription factors that motivate the liver lipid metabolism.

In addition, metabolic regulators also play important roles in determining grain number in plants.