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We demonstrate that diurnal regulation results in dynamic molecular changes during cold acclimation; and this metabolic reconfiguration involves transcriptional regulation, mostly associated with "conventional" cold-stress metabolites, such as raffinose, proline and γ-aminobutyric acid (GABA).
However, the accumulation of other cold-responsive metabolites, for instance homoserine, methionine and maltose, did not have consistent transcriptional regulation, implying that metabolic reconfiguration involves complex transcriptional and post-transcriptional mechanisms.
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Cell reconfiguration involves transferring of the existing machines between different locations and purchasing and adding new machines to cells.
Knowledge reconfiguration involves the conversion and formalisation of these novel practices within existing firm and industry organisation.
The reconfiguration involved the centralisation of elective gynaecology on one hospital site and emergency gynaecology on the other.
Investigation of the rice transcriptome following BPH feeding revealed the activation of a wide and complex response, and the transcriptional reconfiguration involved a broad range of biological processes.
The investigation of the tomato transcriptome following aphid attack highlighted the activation of a wide and complex response, as the transcriptional reconfiguration involved a broad range of biological processes in a different way.
To test the relevance of metabolic reconfiguration during M1 polarization, we employed inhibitors to interfere with glucose metabolism and measured cytokine production as a functional readout.
Consequently, the adaptive modulating the expression of nuclear genes such as metabolic enzyme genes and stress response genes leads to a compensation for the metabolic reconfiguration, in which various mitochondrial or cellular effects can be achieved (Fig. 2) (Butow and Avadhani, 2004).
Metabolic reconfiguration during cold is also dependent on stress duration [14] and developmental stage [14], [15].
The net impact of this concerted metabolic reconfiguration led to a dramatic decrease in NADH, a major contributor to the production of ROS in vivo.
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