Sentence examples for metabolic program that from inspiring English sources

Some researchers suspect the problem may lie with a metabolic program that is set before birth.

HIF activation orchestrates a metabolic program that promotes the catabolism of glucose through aerobic glycolysis and thus shifts glucose away from the TCA cycle (Semenza, 2012).

Additionally, Muc-1 acts as a master regulator of the metabolic program that can also help tumor cells survive and proliferate in hypoxic environments [ 43].

This coordinate induction of aerobic glycolysis suggests that Drosophila larvae utilize a metabolic program that is similar to the classic Warburg effect model, in which cancer cells exhibit elevated glycolytic flux and decreased oxidative phosphorylation.

We previously identified a gene expression signature of commonly dysregulated metabolic enzymes that were heightened across a panel of highly aggressive human cancer cells, leading us to hypothesize that there was a metabolic program that supports cancer malignancy.

In addition, it has been shown that by activating BAT via short-term cold exposure, fatty acids are efficiently channeled into BAT due to a metabolic program that boosts TG-rich lipoproteins (TRL) uptake into BAT.

Under the survival- and growth-unfavorable conditions of the hypoxic microenvironment, all cells, including T lymphocytes, need to adapt metabolic programs that support their survival [148, 189, 190].

If the hypothesis is correct, efforts to address childhood obesity would most effectively lower future health risks if they include focused efforts to interrupt early metabolic programming that elicits the spendthrift phenotype.

A previous study showed that mutp53 recruits the SREBP-1 transcription factor to enact a metabolic transcription program that promotes sterol and lipid biosynthesis [ 4].

However, MED13 knockout in skeletal muscle resulted in resistance to hepatic steatosis in mice by activating a metabolic gene program that enhances muscle glucose uptake and storage as glycogen (Amoasii et al. 2016).

The gene expression changes in the larval offspring also demonstrate significant differences in the metabolic gene regulatory program that could be responsible for the altered body composition changes we found.