Mechanisms regulating energy balance and metabolic profile involve complex interactions between genetic, environmental and behavioral factors.
The present study, using a H NMR multivariate analysis of goat VH samples, showed a clear time-related change of the metabolic profile, which involves mainly central energy, amino acids, and ketones metabolisms.
Although there were some proofs that an altered metabolic profile was involved in CPP, interpreting the biological implications at a systematic level is still in pressing need.
Notably, the present findings highlight subtle differences between these cell types that went unnoticed in our previous large-scale metabolic profiling work that involved over 140 distinct ions.
The metabolic profile of CRC involves several significantly altered metabolic pathways, including increased glycolysis and an impaired tricarboxylic acid cycle, dysregulations of glutaminolysis and down-regulated urea cycle.
A study using in vitro H NMR reported that patients with IBD showed similar metabolic profile in macroscopically involved and uninvolved colonic mucosa compared with that of controls [ 76].
Thus, the integrated approach involving correlation analyses, metabolic profiling, and database searching is efficient for high-throughput metabolomics.
In order to integrate leaf transcriptome data with the metabolic profiling, attention was focused on the DEGs involved in metabolic pathway.
mQTL and mGWAS involve independent QTL mapping of each metabolite identified by metabolic profiling, though accurate analysis is dependent upon proper preprocessing of both genomic and metabonomic data.
The efficient combination of chemokine receptor ligand binding assays with analytical techniques, involving nanofractionation as linking technology, allows implementation of comprehensive metabolic profiling in an early phase of the drug discovery process.
