Also, a variety of terms related to metabolic processes, including carbohydrate metabolism, protein metabolism, or secondary metabolism, were over-represented in gene families.
Our analysis confirms that methapyrilene-mediated hepatotoxicity is accompanied by induction of genes involved in protein translation, structural remodeling, cell death/apoptosis, and the repression of several metabolic processes including lipid metabolism, steroid metabolism, and fatty acid β-oxidation.
For example, dioxin-induced processes that exhibited changes in many more genes included the stress response, embryonic morphogenesis, gene transcription, protein metabolism, and DNA metabolic processes including proteins involved in DNA replication and/or repair.
Our findings suggest that Fam40b during development suppresses the expression of genes associated with RNA metabolic processes, as is indicated by our observation of an upregulation of RNA metabolic processes, including ncRNA processing, upon knockdown of Fam40.
The transcripts over-expressed in sDCs were enriched for metabolic processes, including metabolism of nitrogen compounds and RNA, while the transcripts over-expressed in vDCs were enriched for immune-related biological processes, including defense response, phagocytosis and cell adhesion.
Nearly all of the 75 significant GO functional categories identified, including those most significantly overrepresented, contain genes that encode products involved in metabolic processes, including metabolism of amino acids, carbohydrates, and nucleotides (Table 2).
Visceral adipose tissue is a metabolically active tissue that is highly involved in regulating different specific metabolic processes, including lipid metabolism, glucose homeostasis, angiogenesis, hemostasis, and blood pressure as well as the modulation of inflammation responses [ 1– 5].
The liver is an essential organ in mammals and the central organ for metabolic processes including xenobiotic metabolism.
Many cellular and metabolic processes, including lipid metabolism, energy homeostasis, and cell differentiation, are controlled by PPARα.
Most of these genes play particularly important roles in different metabolic processes, including energy metabolism or downstream molecular functions affecting metabolic processes.
