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So while the impact of APOE is clearly of importance in AD, our data indicate that other participants in sterol metabolic processes also impact upon susceptibility.
The genes of these three metabolic processes also were upregulated in RBF1 and HFL1 mutants.
The multiple functions and effects of the liver influence metabolic processes also in other tissues.
Transcription of genes encoding functions specific to one condition display high-fold differences, as evidenced by genes involved in conversion of the sole carbon source, xylose, to the pentose phosphate pathway intermediate, xylulose-5-phosphate (Table 2), whereas central metabolic processes, also needed in the other condition (growth on maltose) are characterised by low-fold differences.
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Genes annotated to disaccharide and pyridoxine metabolism, vitamin B6 biosynthesis and aspartate family amino acid metabolic process also had highly variable transcript abundance throughout fermentation.
In addition, "organelle", "catalytic activity" and "metabolic process" also had large proportions (> 45%) of unigenes.
However, in the same QTL region, soluble starch synthase 3 (LOC_Os04g53310) under the GO term of carbohydrate metabolic process also existed.
In accordance to the altered expression of proteins of the endoplasmic reticulum (GO 0005783, n=8, P=0.009), the cluster 'cellular metabolic process' also contains proteins involved in unfolded protein binding (GO 0051082, n=11, P<0.001).
Among them, there were genes related to chlorophyll and carotenoid biosynthesis, carbohydrate and sugar metabolic processes and also to acid metabolism (Additional file 14: Table S7).
These results demonstrate that hub and node structures, also known as scale-free networks [ 25] that have been described for normal metabolic processes are also observed in both neutrophils and PBMC gene expression signatures of these diseases.
Metabolic processes can also be probed through the fine tuning of gene activities by silencing genes with small interfering RNA (siRNA) and microinterfering RNAi.
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