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Is it the venom — or some metabolic precursor of the venom — that makes the rascasse essential ?
Sulindac is the metabolic precursor of the potent non-steroidal anti-inflammatory drug (NSAID) sulindac sulfide, which suppresses prostaglandin production by inhibition of cyclooxygenases (COX).
Systemic administrations of both the immediate metabolic precursor of KYNA, l-kynurenine (l-KYN), and a proved inhibitor of KYNA's brain transport, probenecid (PROB), have shown to produce neuroprotective effects in a considerable number of experimental toxic conditions; however, this strategy has not been tested in the toxic model Aβ peptide so far.
In vertebrate systems, N-acetylneuraminic acid (Neu5Ac) is the metabolic precursor of all known naturally occurring sialic acids [6].
Additionally, proline metabolic properties in the CNS suggest that this aminoacid can act as an inhibitory neurotransmitter and/or as a metabolic precursor of glutamate in subpopulations of glutamatergic neurons [71], [72], [77].
A growing body of evidence has suggested that PIP2, a phospholipid enriched at the plasma membrane, serves not only as a metabolic precursor of InsP3 [21], but also as a signaling molecule mediating diverse cell functions such as actin polymerization, regulation of ion channels, assembly and disassembly of vesicular coats, and mRNA processing [22] [26].
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To achieve efficient productivities of target compounds, an engineered E. coli should accumulate metabolic precursors of target compounds.
Work soon followed on the O-methyl transferases (OMTs) involved in modifications of chalcone, isoflavonoids and metabolic precursors of lignin.
The biochemical basis of this rule results from the fact that the enzymes which participate in either the sequential oxidation of aliphatic alcohols to fatty acids, or the reduction of long chain fatty acids to aliphatic alcohols (metabolic precursors of ether lipid synthesis), are not entirely selective with respect to acyl chain length or degree of unsaturation.
Pkh-kinases are regulated by LCBs, which are metabolic precursors of sphingolipids.
A subset of essential genes encodes the metabolic enzymes, which catalyze biosynthesis of the essential metabolic precursors of biomass.
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