As metabolic perturbation caused by acidosis had been associated with the inhibition of glycolysis and glycogenolysis [63], increased phosphocreatine (PCr) degradation and inorganic phosphate (Pi) accumulation ([PCr]/[Pi]) within the myocyte [64], the authors speculated that the delayed accumulation of intracellular H+ induced by NaHCO3 was the primary cause of the performance effect.
For genome-scale networks, the metabolism of a whole organism is considered, which may be large (Thiele and Palsson, 2010), whereas a metabolic perturbation caused by some stress condition may impact only a small portion of this complex network.
Taken together, these results confirm that the ptcu-1_1.5 copper expression trigger results in a minimal metabolic perturbation as reflected by H NMR. In this study, we develop nit-6 as an inducible/repressible promoter for N. crassa.
How many years has the cell spent in stress, brought about by metabolic perturbation (Fig. 6A)?
In this context, the current study confirms the idea that 1-h GIGT represents the more severe metabolic perturbation in pregnancy, characterized by greater glycemia, lower insulin sensitivity, and markedly reduced β-cell function (measured by insulinogenic index/HOMA-IR).
Moreover, cell synchronisation by membrane elution has revealed a similar cell cycle-dependent periodicity in Mcm5 and Mcm7 expression (Eward et al, manuscript submitted), findings that may have been previously obscured by metabolic perturbation due to the use of chemical synchronisation agents.
Curiously, the precise cell-non-autonomous and cell-autonomous relevance of endogenous FGF21 action remained poorly understood.We made use of the established UCP1 transgenic (TG) mouse, a model of metabolic perturbations made by a specific decrease in muscle mitochondrial efficiency through increased respiratory uncoupling and robust metabolic adaptation and muscle ISR-driven FGF21 induction.
It may be difficult to separate the photosynthetic impact of photoinhibition with other metabolic perturbations caused by abiotic and biotic stresses.
The present study first aimed at providing an unbiased description of the metabolic perturbations induced by prednisolone treatment in human using untargeted urine metabolic profiling.
The data suggest that in aggregate, NO activity is protective against some of the metabolic perturbations induced by a high fat diet.
