Sentence examples for metabolic pathways targeted from inspiring English sources

However, it should be noted that when used in vivo, such metabolism-targeting drugs might mediate unwanted side effects on healthy tissues and organs that depend on the metabolic pathways targeted.

Here we reported the oral delivery of a non-protein drug artemisinin biosynthesized (∼0.8 mg/g dry weight) at clinically meaningful levels in tobacco by engineering two metabolic pathways targeted to three different cellular compartments (chloroplast, nucleus, and mitochondria).

In conclusion, despite the absence of highly significant transcriptional changes within the metabolic pathways targeted by T4, this analysis validates the existence of a specific transcriptional cascade across the P. falciparum cell cycle [ 17, 55].

Yet, without detailed information on central carbon metabolism in breast tumors it is impossible to know which metabolic pathways to target, and how their inhibition might influence different stages of breast tumor progression.

Metabolic chokepoints or essential proteins in metabolic pathways have been targeted for drug prioritization[10], [11], [12], [13].

Next, we sought to unravel what component of the plant gene interaction networks and metabolic pathways have been targeted by the virus during its adaptation to A. thaliana Ler.

Studies with various dietary fatty acids have revealed several major metabolic pathways that are targeted by PUFA, each pathway involving changes in gene expression [ 35- 37].

It is our hypothesis that prebiotic supplementation, as an adjunct to lifestyle-mediated weight loss, will improve hepatic and metabolic pathways beyond those targeted by weight loss alone.

Each of these core metabolic pathways that were targeted for analysis is structured as a co-expressed module whose transcripts co-accumulate over a wide range of environmental and genetic perturbations and developmental stages.

In the field of drug residue analysis, knowledge of the main metabolic pathways of target analytes improves the efficiency of the corresponding control.

To support the "birds' eye view" approach, we provide a road-map depicting commonality and interrelationships between the traits and their genetic and environmental determinants based on known risk factors, metabolic pathways, pharmacologic targets, treatment responses, gene networks, pleiotropy, and association with circadian rhythm.