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Overall, CpC231 had 13 specific metabolic pathways not found in strain Cp1002, and the latter had 11 metabolic pathways not found in strain CpC231 (Table 6).
C. glutamicum has several metabolic pathways not found in C. pseudotuberculosis Cp1002 and/or in C. pseudotuberculosis CpC231.
KEGG PATHWAY analysis comparing the distribution of the gene expression of each pathway visualised in a graphic model, showed among others that the purine and pyrimidine metabolic pathways (not shown), cell cycle and proteasome, were selectively overexpressed in tumour (Fig. 3).
Concomitantly, can occur a shutdown of other metabolic pathways not directly involved with defense response, such as those associated with growth and reproduction.
This type of analysis can provide important information about cell physiology and has the potential to identify connections between regulatory or metabolic pathways not previously known [ 22, 23].
A growing body of recent studies has shown that XPA plays an important role not only in NER but also in some other DNA metabolic pathways, not necessarily related to DNA damage.
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27 Together with other orexigenic and anorexigenic genes, expression of PRCP and MC4R was unchanged in the B1B2KO mouse hypothalamus after treatment with the control diet or the HFD, indicating that the reduced food consumption observed in these mice was probably related to an alternative metabolic pathway not examined in this study.
These genes are again enriched for signaling pathways regulating metabolism, but not enriched for metabolic pathways (data not shown).
A hierarchical clustering analysis based on all the 53 metabolites belonging to the first ten ranked metabolic pathways could not distinguish between patients with and without capillary leak syndrome (data not shown).
But the deep conservation of metabolic pathways does not imply that all animal cells have the same metabolism.
Although there are no specific data on the metabolism of this drug administered transdermally, it is reasonable to believe that metabolic pathways do not differ between different routes of administration.
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