This model of metabolism as composed by independent metabolic pathways is simplistic, since pathways are nested and interdependent.
These results show that a metabolism-centered comparative analysis of metabolic pathways is helpful in identifying and evaluating present gaps in our knowledge.
A framework for reverse engineering of metabolic pathways is proposed.
The available spectrum of experimental and FDA-approved drugs that modulate individual steps in these metabolic pathways is also summarized.
In the later stages, detailed understanding of metabolic pathways is equally important for, e.g., safety assessment.
Designing putative metabolic pathways is of great interest in synthetic biology.
The ability to rationally engineer secondary metabolic pathways is a promising approach to novel therapeutics.
The critical substrate level separating the two different metabolic pathways is generally not well defined.
Therefore, the understanding of metabolic pathways is a key feature for targeting the pathogenic bacteria without disturbing the symbiotic ones.
These findings illustrate that targeting host arginine-associated metabolic pathways is an effective means of controlling viral replicative processes.
The optimization of metabolic pathways is of fundamental importance for strategies aimed at improving the economics and yield of the lignocellulose-to-ethanol processes.
