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These observations suggest that maternal protein restriction can affect major metabolic pathways implicated in regulation of lifespan at a young age which may explain the impact of maternal diet on longevity.
Identifying putative biomarkers and metabolic pathways implicated in this disparity of response is a goal of the present study.
In addition, transcriptomic data at birth revealed activation of metabolic pathways implicated in chronic disorders such as obesity and type II diabetes [ 77].
The heterogeneity of organ dysfunction in both severe malaria and severe sepsis complicates our understanding of both conditions, particularly with regard to the metabolic pathways implicated.
Overall, the conversion of nitrogen compounds to ammonia expends some energy and, therefore, the metabolic pathways implicated in this process are strictly regulated to minimize energy waste.
The microarray data suggest genes encoding enzymes in early steps of metabolic pathways implicated in pheromone component biosynthesis are not clearly coordinately regulated.
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In unpaired EOT liver biopsies, intrahepatic expression of fatty acid metabolism and lipid transport genes was lower in patients who experienced treatment relapse.Clearance of HCV using an IFN-free antiviral regimen results in rapid changes in peripheral and intrahepatic metabolic pathways, implicating a direct effect of HCV replication on lipid homeostasis.
The mevalonate (MVA) pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis.
The insulin/IGF-1 (IIS) signaling pathway is the most characterized metabolic pathway implicated in aging [ 2, 3].
The PGD2 metabolic pathway implicating L-PGDS appears to be activated in Crohn's disease.
Our findings highlight metabolic pathways potentially implicated in disease pathogenesis.
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