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Engineering the metabolic pathways has concentrated on improving the lactic acid fermentation parameters, enhancing the acid tolerance of production organisms and their abilities to utilize a broad range of substrates, including fermentable biomass-derived sugars.
As part of an international effort and a national programme, structural analysis of mycobacterial proteins involved in recombination and repair, stringent response and protein synthesis has been undertaken, and work on proteins in a couple of metabolic pathways has been initiated.
The hepatic genes expression that can regulate the ability of enzymes related with metabolic pathways, has always been received widespread attention.
A detailed representation of the corresponding metabolic pathways has been published by Jones and Woods [ 10].
Dysregulation of the prostacyclin metabolic pathways has been shown in patients with PAH.
A relationship between iron and fibroblast growth factor-23 (FGF23) metabolic pathways has been proposed.
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In situ ultrastructural analysis is suitable to study cellular metabolism because metabolic pathways have variable structural bases.
In fact, while EC metabolism is largely understudied, several of the above-mentioned metabolic pathways have been implicated as mediators of pathological angiogenesis or EC dysfunction.
In the past two decades, several databases of biochemical reactions and metabolic pathways have been developed to provide a systematic and comprehensive overview of metabolism.
Abnormal cellular metabolism is a defining feature of cancer [ 1], and proteins involved in metabolic pathways have both diagnostic and therapeutic potential [ 90, 91].
Exciting results have been obtained in preclinical cancer models where different metabolic pathways have been targeted by selective drugs7,8,9,10.
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