Sentence examples for metabolic pathways given from inspiring English sources

We hypothesized that sorafenib cardiotoxicity is related to its deleterious effects on specific cardiac metabolic pathways given the critical roles of protein kinases in cardiac metabolism.

A computational framework has been developed for the construction and evaluation of metabolic pathways given input substrates and knowledge of enzyme-catalyzed reactions.

In this article, we assess the capability of sub-network extraction algorithms to predict metabolic pathways given a metabolic network and a set of seed reactions.

In contrast, the presented method aims to predict metabolic pathways given a metabolic network and a set of seed nodes, which can be compounds, reactions or enzyme-coding genes.

The optimization of metabolic pathways gives useful insights on cellular metabolism for improving process yield by engineering cyanobacteria.

Our prior is motivated by the biological assumption that variation in underlying developmental processes such as gene networks or metabolic pathways gives rise to genetic and residual covariances.

To increase the proliferative activity cancer cell typically needs to modify its metabolic pathways giving rise to a metabolic reprogramming which is generally explained by the metabolic shift from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis (Warburg effect) [ 3, 4].

As a result, scientists studying the evolution of metabolism have worked under the assumption that glucose was the first anaerobic (O2 free) source of energy and glycolysis the earliest metabolic pathway, given its products and its current position with respect to the citric acid cycle.

It is likely that there was not enough endogenous polyphosphatase to complete the polyphosphate metabolic pathway given that the ppx gene was not genetically engineered along with the ppk gene.

It might therefore be possible for different genetic alterations to converge on the same metabolic pathway, giving similar VOC signatures or confounding the detection of either mutation; this may partly explain the lower accuracy seen when detecting RAS mutation across multiple cancer-derived cell lines harbouring additional mutations (Peled et al, 2013).

Given that metabolic pathways have been extensively modified along the evolution of Prochlorococcus, the widespread glucose utilization in this microorganism suggests that this process is very important for its survival.