Automated model development can exclude unique metabolic pathways if they are absent from the training set of models.
269 pathways were downloaded from KEGG database [ 77] on Jun. of 2013, and 200 of them are used in this study after excluding 3 global metabolic pathways and 66 human disease pathways.
Reverse causation, for instance, cannot be excluded because TH regulates a number of metabolic pathways, including lipid metabolism and the activity of some cytochrome P450 enzymes (Takahashi et al. 2010; Yen 2005), which may alter PBDE serum concentrations.
Moreover, since alanine is involved in many complex and important metabolic pathways [ 46, 47], our experiments cannot exclude that the elevated alanine transport might be related to other metabolic mechanisms of vital importance for normal brain activity.
In big cats, several genes are altered in the metabolic pathways linked to protein digestion and metabolism.
This divergent expression pattern of ApCPS1, ApCPS2 and ApCPS3 indicated their role in different diterpene metabolic pathways of kalmegh, although, their involvement in same biosynthetic pathway with functional redundancy cannot be completely excluded.
These observations, however, do not exclude the fact that smoking may increase risk of type 2 diabetes in non pregnant women through different metabolic pathways.
From the top-level pathways on the front page of the Reactome website, we selected the ten pathways focused on (normal) metabolic processes, excluding, e.g., signaling and disease-related pathways (see Additional file 14 for a complete list).
The bath, she added, "opens metabolic pathways".
"We ought to have all these metabolic pathways.
