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129 However, few studies have discussed the relationship between body fat accumulation and amino acid metabolism in order to verify the possible modifications in amino acid metabolic pathways caused by an elevated fat intake.
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Therefore, disruption of these metabolic pathways causes hepatosteatosis.
Meanwhile, glycogen supplied phosphate flows into the central metabolic pathway, causing PEP accumulation.
This metabolic pathway causes a large loss of CO2 by the pure culture, thus lowering the PHA production efficiency.
Allosteric interactions with metabolites upstream or downstream in an enzyme's metabolic pathway cause feedback regulation, altering the activity of the enzyme according to the flux through the rest of the pathway.
Meanwhile, several metabolic pathways have been shown to cause nerve damage [ 12], and it therefore appears that both vascular and metabolic mechanisms may be involved in the pathogenesis of diabetic neuropathy [ 1, 6].
By contrast, anaerobic metabolic pathways have received less attention.
Two experimental rat studies have found that half-life of the PFAS differs according to sex (Ohmori et al. 2003; Vanden Heuvel et al. 1991); furthermore, multiple studies have reported that endocrine disruptors could change the metabolic pathways and cause permanent changes in body weight as reviewed by Newbold et al. (2008).
Reactive oxygen species (ROS) produced from various metabolic pathways can cause oxidative damage [ 42].
As indicated previously, metabolic engineering of metabolic pathways could cause unplanned and unforeseen deleterious effects on cellular function.
Increased serum uric acid may thus only be an epiphenomenon of other pathologic metabolic pathways that cause increased CV risk [ 36].
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