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Based on these comparisons, we detected a core of metabolic pathways associated with central carbohydrate metabolism, lipid, cell wall, and cofactors, and biosynthetic pathways.
This group is enriched for metabolic pathways associated with the central metabolism, including glycolysis, OxPhos, serine, glycine and folate metabolism (Supplementary Table 2, Type 1).
Overlap between embryonic liver development and liver cancer is not only in cell cycle or apoptosis, but also in metabolic pathways associated with carbohydrate and lipid metabolism [ 30].
The recurrence of lack of lipogenesis is remarkable because major metabolic pathways associated with sugar and lipid metabolism are typically highly conserved across taxa (Grönke et al. 2005; Turkish and Sturley 2009; Arrese and Soulages 2010) and lipid reserves play a key role in both survival and reproduction.
In order to evaluate whether there is any enrichment of specific metabolic pathways associated with specific diseases, we added to the gene-disease associations a link to metabolic pathways, and hereby created associations between metabolic pathways, genes and diseases.
Fig. 1 Metabolic pathways associated with ornithine biosynthesis in C. glutamicum and the metabolic engineering strategies of ornithine production.
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Furthermore, the induction of the metabolic pathway associated with the synthesis of phenylpropanoids in plants treated with biostimulants may explain why these products can help plants to overcome stress situations [14,15].
Increases in the TCE blood levels led to higher availability of the parent compound for glutathione conjugation, a metabolic pathway associated with kidney toxicity/carcinogenicity.
By contrast, if the predicted behaviors are significantly different in some of the metabolites (see, e.g., blue dots in Figure 1a), there may be an unknown metabolic pathway associated with these metabolites or an unidentified regulatory signal.
Three modulated pathways, C21-Steroid hormone metabolism, oxidative phosphorylation, and metabolic pathways, are associated with metabolism, indicating the basal metabolism of cells in testis are affected.
Metabolic processes and pathways associated with genes identified commonly in previous reports (Komatsu et al. 2009a; Nanjo et al. 2011a; Tamang et al. 2014) are listed.
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