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In contrast, a recent study on four cestodes identified extensive losses of genes and pathways that are broadly conserved in other animals as well as the origin of specialized metabolic pathways adapted to extract nutrients from the host [ 91].
44 As the Paleolithic diet was low in fat, simple carbohydrates, and salt, mechanisms from behavior to metabolic pathways adapted to obtain and maximize use of these important nutritional resources.
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A majority of these genes are involved in metabolism and presumably allow the amoeba to use bacterial metabolic pathways to adapt to the low oxygen environment of the gut.
Plant, fungi, bacteria and viruses often utilize unique metabolic pathways that are adapted to their life cycles and environments.
Figure 1 Metabolic pathways of photosynthetic microorganism (adapted from [ 67 ]).
The Na+/K+-ATPase is an ubiquitous plasma membrane pump whose enzymatic activities constitute some of the principal means through which all animal cells convert the energy embodied in ATP into electrochemical gradients that can be exploited by all manner of metabolic pathways; its structure is adapted in marine organisms.
For instance, if one is interested in studying a metabolic pathway which is adapting due to activation of a signal transduction pathway, the modulating effects can be captured by identifying necessary changes in the metabolic pathway parameters rather than developing a mathematical model that includes an explicitly modeled signal transduction pathway.
Gene expression of the enzymes involved in macronutrient metabolism changes according to diet composition and nutritional state in order to adapt the metabolic pathways to the available nutrients and metabolic requirements.
When cancer cells generate ATP due in part to mitochondrial respiration injury, they adapt alternative metabolic pathways, such as increasing glycolytic activity, to maintain their energy supply (the Warburg effect).
In fact, neoplastic cells adapt their metabolic pathways to face the demands of abnormal proliferation.
The term 'metabolic engineering' will not only be applied to the manipulation of metabolic pathways, but we will also adapt this term for those strategies where the action of transcription factors and signalling proteins has been modified.
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