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To gain further insight into the mechanisms underlying the change in the phenotype of BAT of the experimental models, we focused on the transcriptional control of the metabolic pathways, achieved by the coordinated actions of numerous transcription factors and associated coregulators or corepressors.
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Next, we picked up some milestones of engineered metabolic pathway achieved in the past few years.
To demonstrate the utility of EMRA, we investigate the bifurcational robustness of two synthetic central metabolic pathways that achieve carbon conservation: non-oxidative glycolysis and reverse glyoxylate cycle.
Here we demonstrate how biocompatible chemistry can be used for synthesizing valuable compounds as well as for linking metabolic pathways to achieve redox balance and rescued growth.
Due to the metabolic adaptability of cancer cells, it may be necessary to combine agents that target different metabolic pathways to achieve high therapeutic activity.
The method developed in this article may be useful for manipulating a metabolic pathway to achieve some desired goals constituting some tasks of metabolic engineering.
Last, cross-species metabolic comparison represents one more utility of such reconstructions through which identification of differentially activated metabolic pathways can be achieved among other comparative analyses [ 5].
Cost-competitive biomanufacturing requires the design of metabolic pathways that can achieve high production yields and rates.
By what metabolic pathway is this achieved in the body?
Regulation of this metabolic pathway is generally achieved through feedback inhibition of the second enzyme in the pathway, N-acetylglutamate kinase (ArgB) by l-arginine [ 10] and/ or by feedback inhibition of ArgJ by l-ornithine [ 8].
A complementary teleology suggests that maintaining high rates of glycolysis is required to reconfigure metabolic pathway fluxes to achieve more efficient anabolic metabolism and cell-autonomous growth.
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