In addition, variants in genes of the 5-FU metabolic pathway, including TYMS, MTHFR and DPYD also influenced capecitabine efficacy and toxicity.
Other enzymes which play minor roles in this metabolic pathway include CYP1A1, CYP2C8, CYP2C9 and CYP3A5.
For example, Fig. 1 shows the expression changes of genes in the central metabolic pathway including glycolysis, the tricarboxylic acid (TCA) cycle, and the pentose phosphate pathway.
The top KEGG metabolic pathways included carbohydrate metabolism, energy and lipid metabolism, amino acid metabolism and the biosynthesis of secondary metabolites.
The next major finding consists of activation of a number of metabolic pathways, including metabolism of lipids, carbohydrates, and amino acids.
Many metabolic pathways, including lipid metabolism and amino acid metabolism pathways, were found to be enriched of DE genes, thus might be significantly divergent between broilers and layers.
UGT1A7 encodes a UDP-glucuronosyltransferase involved in multiple metabolic pathways, including the metabolism of hormones and the metabolism of xenobiotics by cytochrome P450.
Recently, we demonstrated that in addition to the drastic metabolic changes in SAA metabolism, L-cysteine also regulates other metabolic pathways including phospholipid and energy metabolism [ 12].
The genome of B. longum subsp. infantis, a typical bifidobacterium in the gut of breast-fed infants, encodes proteins associated with several kinds of species-specific metabolic pathways, including urea metabolism and biosynthesis of riboflavin and lantibiotics.
All the three substrates supported growth and PHB production by C. necator, but substrate-specific effects were observed for cell mass production, PHB accumulation, and protein expression levels of several key metabolic pathways, including glycerol metabolism, the fatty acid β-oxidation pathway, the Glyoxylate Shunt, and hydrogen (H2) synthesis pathways.
