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Nutrient and oxygen availability are key metabolic parameters for biopharmaceutical manufacturing.
Table 6 Calculated metabolic parameters for compounds 1 and 2 based on NADPH dependent degradation profiles in human liver microsomes Compound In vitro CL int (µL/min/mg protein) Microsome predicted CL int (mL/min/kg) Microsome predicted E H Metabolites detected 1 12.3 14.3 0.41 None detected 2 7.4 8.6 0.29 None detected.
Metabolic parameters for 10-week-old male control Wistar and diabetic GK rats are summarized in Table 1.
Lactate clearance and base excess have been proposed as metabolic parameters for indirectly assessing tissue perfusion.
In this field study, we set out to establish optimal predictor cut points of these metabolic parameters for the detection of CE and SCE.
Logistic regression analysis was performed to assess the odds ratio (OR) of the metabolic parameters for the presence of overt NAFLD after adjustments for age and sex.
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The maximum standardised uptake value (SUVmax) has been the most commonly used PET metabolic parameter for staging and monitoring of treatment response.
There were no significant associations between the residual metabolic burden below OC for all three metabolic parameters of the index nodes and oncological outcomes.
As expected, mechanical and metabolic parameters differed for the two load levels.
Under basal conditions, GPR120-null mice did not show any significant change in body weight or in the main metabolic parameters evaluated (for example, glycaemia or triglyceridemia; Supplementary Table 2).
In women, significant correlations (p < 0.01) were also found with almost all metabolic parameters except for alcohol consumption.
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