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Understanding the mechanism of metabolic network response to extracellular changes has become one of the primary objectives of systems biology.
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This approach for determining the temporal structure in metabolic network responses was used as a basis for the analysis how it responds to perturbations.
The evaluation of the computed nRBC metabolic network responses and the resulting internal changes from the imposition of redox or energy loads led to the observation that changes in transport fluxes reflected changes in internal functional states (Additional file 2, Figure 1): As the redox load increased, flux through glycolysis decreased and flux through the pentose phosphate pathway increased.
However, the global metabolic network in response to AHG remains unclear.
Such metabolic changes may be explained by minor perturbations or deregulations in the metabolic network in response to exposure to these protein extracts via the i.g. route.
For the purposes of developing genetic engineering strategies for enhancing butanol yield, we wish to examine changes to the steady states of the metabolic network in response to variations in transcription rates of the solvent-associated genes.
Cells continuously rewire their metabolic networks in response to changes in environmental conditions to sustain fitness.
Using comparative genomics and flux balance analysis, Pal et al. [ 8] concluded that the adaptive evolution of bacterial metabolic networks in response to changing environments proceeds essentially by horizontal gene transfer (i.e. genes acquired from other species) of genes involved primarily in the transport and catalysis of external nutrients.
To the best of our knowledge, an increase in metabolic network connectivity in response to water stress has not been observed in any organism.
The flexibility and versatility of gene-linked metabolic network interactions in response to alterations in nutritional environment underlies metabolic control theory (Greenspan, 2001; Veech et al, 2001; Strohman, 2002; Greene et al, 2003).
Furthermore an analysis of the paths identified by HME3M for each metabolic network confirmed known biological responses of Arabidopsis.
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