The changes that drive antitumor drug resistance include the following: increased activity of drug efflux pump, such as the ATP-binding cassette (ABC) superfamily; decreased drug influx; activation of DNA repair; metabolic modification or detoxification; and altered expression of apoptosis-associated protein Bcl-2 [5] and tumor suppressor protein p53 [7], [7].
Lovastatin and simvastatin are prodrugs which require metabolic modification in the gut and liver with hydrolysis of a lactone group to produce the active acid form.
This study provided essential information for enhanced understanding of the degradation pathway of A. resinae ZN1 for the future improvement of detoxification efficiency and metabolic modification of the strain.
Equally importantly, our discoveries have significant implications for carotenoid metabolic engineering by providing the knowledge needed to give close consideration to a wider range of characteristics, such as plant resistance and systematic metabolic modification.
More evidence is needed to determine whether maternal "metabolic modification" [ 26] can safely and efficaciously lower the risk of NTD.
This led us to make changes in the processing conditions of the tissues samples and we continued using doped samples to circumvent a possible metabolic modification of IG20.
Another study showed that Rh2 metabolic modification ginsenoside aglycone protopanaxadiol (aPPD) activated in treating prostate cancer combined with docetaxel and was more effective than its prototype [ 77].
Dumont, A., Malleron, A., Awwad, M., Dukan, S. & Vauzeilles, B. Click-mediated labeling of bacterial membranes through metabolic modification of the lipopolysaccharide inner core.
The natural coordination among different metabolic pathways contributes to the complexity of metabolic modification, which hampers the development of biorefineries.
The metabolic modification (via pta introduction) of the isopropanol-producing strain enabled production of isopropanol under photosynthetic conditions.
