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Genome-scale metabolic models are increasingly becoming available for a variety of microorganisms.
As larger metabolic models are developed with increasing genetic information and experimental validation, the demand to incorporate kinetic information increases.
For model organisms metabolic models are well established, with many manually curated genome-scale model reconstructions, gene knockout studies and stable-isotope tracing studies.
Microbial transcriptomics may yield improved predictions of metabolic processes and enzymatic pathways present in well-defined environmental conditions, but interpretations of such metabolic models are cumbersome [23], [24].
Metabolic models are an important tool for metabolic engineering.
Genome-scale metabolic models are important tools in systems biology.
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Molecular level metabolic models were constructed to represent the central metabolism of three functional guilds thought to be important to material and energy flows through this community [ 12].
Briefly, 83 normal cell type genome-scale metabolic models were downloaded at www.metabolicatlas.org.org
Genome-scale metabolic models were constructed for Arthrobacter, the atrazine degrader, and four other non-atrazine degrading species whose relative abundance in soil was changed following exposure to the herbicide.
Metabolic models were created for both strains L. reuteri 55730 and 6475, and these models highlighted different probiotic features in each strain.
Three different draft metabolic models were constructed for Thermobifida fusca.
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