Thus, metabolic memory may apply to neuropathy as well as retinopathy and nephropathy, but part of its long-term effect is mediated by treatment group differences in residual subclinical NCS results at closeout among subjects who remain asymptomatic.
The notion of good metabolic memory has been applied to the beneficial effects of an initial period of good glycemic, lipid, and blood pressure control resulting in effects going beyond that of the period of near euglycemia and followed by a rebound hyperglycemia, referred to as the Nike pattern of glycemic control, yet the benefits observed are maintained.
70 Furthermore, the beneficial effect of intensive glycemic control applied early in the course of diabetes appears to have long-lasting effects (metabolic memory).
Reddy, M. A., Zhang, E. & Natarajan, R. Epigenetic mechanisms in diabetic complications and metabolic memory.
Tonna, S., El-Osta, A., Cooper, M. E. & Tikellis, C. Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms.
Miao, F. et al. Evaluating the role of epigenetic histone modifications in the metabolic memory of type 1 diabetes.
Pop-Busui, R. et al. DCCT and EDIC studies in type 1 diabetes: lessons for diabetic neuropathy regarding metabolic memory and natural history.
Bianchi, C. & Del Prato, S. Metabolic memory and individual treatment aims in type 2 diabetes — outcome-lessons learned from large clinical trials.
Chen, Z. et al. Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort.
Metabolic memory is a phenomenon characterized by the persistent expression of DKD-related genes and phenotypes induced by glycaemic exposure despite subsequent glycaemic control.
