A growing body of evidence suggests that redox homeostasis is a metabolic interface between stress perception and physiological responses [ 29].
In this study, we show that the benzoquinone embelin acts on the metabolic interface between angiogenic and quiescent ECs as a weak mitochondrial uncoupler.
The NP/ETC complex represents the transfer path between maternal and filial grain tissues and also functions as a metabolic interface to precondition amino acid supply to the developing endosperm.
This is a very specific form of naturalization of social change that recasts social suffering as molecularly heritable, the past borne forward into the future via a metabolic interface that modulates 'predictive signaling' to subsequent generations about the world they will be born into (Kuzawa, 2005).
The metabolic interface is not located anywhere in particular – it is not a structure or an organ that stands here or there, defining the spaces on either side of it – rather, it is a dynamic net of molecules that both interacts with environmental molecules and is iteratively conditioned in the parameters of that interaction by exposure to the environment.
This goal was achieved by translating the detected metabolite ions into pathways using the metabolic annotation interface MassTRIX which assigns to each m/z value potential annotations from various metabolite data bases [30].
Lin, KH, Xie, A, Rutter, JC, Ahn, Y-R, Lloyd-Cowden, JM, Nichols, AG, Soderquist, RS, Koves, TR, Muoio, DM, MacIver, NJ, Lamba, JK, Pardee, TS, McCall, CM, Rizzieri, DA, and Wood, KC. "Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity". Cell Metabolism (February 5 , 2019.
Lin, KH; Xie, A; Rutter, JC; Ahn, Y-R; Lloyd-Cowden, JM; Nichols, AG; Soderquist, RS; Koves, TR; Muoio, DM; MacIver, NJ; Lamba, JK; Pardee, TS; McCall, CM; Rizzieri, DA; Wood, KC, Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity., Cell Metabolism (2019) [10.1016/j.cmet.2019.01.011] [abs].
The latter page utilizes the Genome-Linked Application for Metabolic Maps (GLAMM) interface and presents the functional overview of a regulon by visualizing its predicted members in the context of metabolic networks [ 41].
The alcoholic crude root-peel extract of Flemingia vestita and its major isoflavone, genistein, have been shown to have a vermifugal/vermicidal effect by causing a flaccid paralysis accompanied by alterations in the structural architecture of the tegumental interface and metabolic activity in Raillietina echinobothrida, the cestode of domestic fowl.
Collectively these studies, working at the interface between metabolic engineering and synthetic biology, demonstrate the positive fundamental and applied outcomes derived from such research.
