Similar reasoning can be followed for V, Vss and Q. Metabolic interactions of topotecan with concomitantly administered IF were not anticipated, because topotecan metabolism to N-desmethyltopotecan is only 0.4 3% of the dose (Herben et al, 1998).
Current hormonal replacement therapy for endocrine disorders cannot, unfortunately, reproduce the complex metabolic interactions of hormones.
There is a growing literature on the metabolic interactions of arsenic and selenium, yet none from this perspective.
PBPK models may also be applied to the evaluation of metabolic interactions of certain chemical mixtures and elucidation of interaction thresholds (Dobrev et al. 2002).
We coupled a mechanistic model of C3 C4 intermediate photosynthesis (von Caemmerer, 2000; Heckmann et al., 2013) with a modified genome-scale stoichiometric model of C4 photosynthesis that was designed to describe the entire metabolic interactions of mesophyll and bundle sheath cells in C4 leaves (Dal'Molin et al., 2010).
Besides, microenvironmental factors (hypoxia, pH, oxidative stress, nutrient availability, cytokines, hormones, and growth factors) and the physical-metabolic interaction of tumour cells with surrounding cells (inflammatory cells, fibroblasts) in the matrix greatly influence the actual level of autophagy in the cancer cells [ 54– 54].
The crucial advantage of rarity comes from the local nature of metabolic interactions on the mineral surface: rare metabolic replicator types have a higher chance to find at least one copy of the more common species within the surface-diffusion range of the metabolites than the common ones to have at least one rare type copy nearby (Additional file 1: Figure S1).
These models are already available for various organisms and provide frameworks of metabolic interactions to the extent of whole cells.
The major objective of this article was to analyze the protein-protein and metabolic interaction networks of Drosophila melanogaster by considering the architectural patterns and the consequence of removal of hubs on the topological parameter of the two interaction systems.
