Sentence examples for metabolic half from inspiring English sources

One reason for the decreased in vivo stability of our probe, compared to earlier examples [6 8], might be that different BODIPY core structures have different metabolic half lifes.

"Serotonin has a short metabolic half-life, so it metabolizes very, very fast.

The N-end rule pathway is a proteolytic system in which single N-terminal amino acids of short-lived substrates determine their metabolic half-lives.

The time course of this synaptic remodeling is slow, similar to the metabolic half-life of neuronal AMPA receptors.

The metabolic half-lives of 68Ga-DOTAVAP-P1 and 68Ga-DOTAVAP-PEG-P1 were 24 and 125 min, respectively.

We hypothesised that prolonging the metabolic half-life of 68Ga-DOTAVAP-P1 could further improve its imaging characteristics.

The goal of PEGylation is mainly to improve the tracer's kinetics and distribution pattern by increasing its metabolic half-life and by lowering its non-specific binding.

We hypothesised that prolonging the metabolic half-life of 68Ga-DOTAVAP-P1 would further improve its potential for in vivo imaging of inflammation.

The eight-carbon mini-PEG spacer prolonged the metabolic half-life of the 68Ga-DOTAVAP-P1 peptide, leading to higher target-to-background ratios and improved in vivo PET imaging of inflammation.

The metabolic half-lives of the 68Ga-DOTA-peptides were calculated according to the results of radio-HPLC, i.e. the time point when 50% of the total radioactivity is still bound to the intact peptide.

We have previously shown that 68Gallium-labelled VAP-1-targeting peptide (68Ga-DOTAVAP-P1) is a positron emission tomography (PET) imaging agent, capable of visualising inflammation in rats, but disadvantaged by its short metabolic half-life and rapid clearance.