In contrary, genes encoding hypothetical proteins, metabolism and miscellaneous groups form the dominant functional class in cluster 2. The induced set of metabolic genes include some carbohydrate metabolism genes like ADH1, FBF, aldolase and pfkB-type carbohydrate kinase family protein of carbohydrate metabolism and oleate desaturase involved in lipid metabolism.
Additional ST203-unique metabolic genes include a riboflavin biosynthesis gene, dihydrofolate reductase and a fructose phosphotransferase system (PTS).
Microarray analysis of 2008-Ets1 ovarian cancer cells revealed that Ets-1 is involved in the regulation of mitochondrial stress and dysfunction as metabolic genes, including those involved in glycolysis, glycolytic feeder pathways, the TCA cycle, and lipid metabolism (Table 2), and genes involved in antioxidant defense (Table 3) were altered in Ets-1 over-expressing cells.
We analyzed 25 SNPs (some previously untested) in 2101 primary lung cancer cases and 2120 population controls from the Environment And Genetics in Lung cancer Etiology (EAGLE) study from six phase I metabolic genes, including cytochrome P450s, microsomal epoxide hydrolase, and myeloperoxidase.
Interestingly mice lacking RIP140 still showed an upregulation of metabolic genes, including those involved in fatty-acid oxidation.
About 19% (192) and 15% (154) of the 1,028 metabolic genes included in iKF1028 were predicted to be essential on M9 and SCFM media, respectively.
This results in the recruitment of p53 to proarrest and metabolic genes, including p21 and TIGAR, leading to antioxidant responses, cell-cycle arrest, and survival.
Salem et al. [ 30] also reported that the expression patterns of several metabolic genes including, ATP and ATPase were associated with faster growth in rainbow trout muscle.
Metabolic genes included aldehyde and alcohol dehydrogenases (Table 4), among others, and were identified in accordance with previously documented roles for GC in various metabolic processes and tissues [ 60, 61].
Expression profiling identified many metabolic genes, including genes involved in mitochondrial biogenesis, fatty-acid oxidation, and oxidative phosphorylation, that were increased in the absence of RIP140, consistent with the function of RIP140 as a corepressor.
In addition, miR-27a inhibits the expression of many lipid metabolic genes, including fatty acid synthase (FASN), SREBP-1, SREBP-2, PPAR α and PPAR γ, as well as ApoA1, ApoB100 and ApoE3.
