However, given the high representation of these functional categories in C. trachomatis genome, we can hardly assume that specific metabolic functions underlie the higher clinical prevalence of strains from serovars E and F. Nevertheless, it seems clear that these serovars share a singular genomic makeup.
FBA only necessitates knowledge about the stoichiometry of a metabolic network as well as the metabolic target functions underlying the cell of interest (e.g., biomass production).
Much greater similarity was observed in higher order functional responses including enrichment of molecular networks and canonical metabolic pathways (Table 1, Fig. 3), especially for molecular functions underlying observed toxicological phenotypes.
Conversely, the biochemical reactions that underlie metabolic functions in cells are well understood [ 4], and have been reproduced in vitro [ 5, 6]; nevertheless, aside from a few exceptions where enzymes form macromolecular complexes [ 7- 9], little is known about the cellular organization of enzymes.
Triglyceride synthesis is a major hepatic function underlying blood glucose and lipid homeostasis — the ability to simulate this function in silico enables the investigation of liver metabolic network states in normal and pathological conditions such as obesity and fatty liver disease.
Assessing epigenomic and other markers underlying altered developmental programming of metabolic functions and endpoints in human studies and in animal models.
In macrophages, the metabolic functions of LXRs are coupled to anti-inflammatory responses, which further contribute to the mechanism underlying their atheroprotective effects.
This work indicates that the decoupling of regulatory and metabolic functions allows one to directly measure the costs and benefits that underlie the natural selection of gene regulation.
Activation of these pathways should be considered as a contributing factor underlying the overwhelmingly benign nature of pituitary adenomas, enabling maintenance of vital pituitary homeostatic and metabolic functions, while protecting the hormone-secreting gland from destruction by malignancy.
It's able to interfere with genetic processes, reproductive abilities and metabolic functions, making it useful in a limited way, and dangerous in a complete one.
