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While ELRGs essentially represent the attempt to rapidly adapt to the harmful effects of light, such as genes involved in synthesis of photoprotective pigments, secondary metabolism, and signaling, LLRGs rather reflect adjustment of metabolic functions to daylight condition, as they comprise genes involved in carbohydrate metabolism, oxidation of fatty acids, and detoxification.
Epigenetic regulation calibrates metabolic functions to match high energetic demand during the onset of neuronal differentiation by increasing maximal mitochondrial respiration activity and generating considerable spare respiratory capacity to confer resistance to oxidative stress and excitotoxicity during differentiation.
The major advantage of this method is that it can easily link metabolic functions to specific species.
However, how the dietary signals are sensed and integrated into transcriptional reprogramming and metabolic functions to maintain systemic cholesterol homeostasis remains largely unknown.
By coordinating the metabolic and circadian transcriptional programs, PGC-1α serves as a molecular switch that synchronizes metabolic functions to the circadian clocks in mouse liver (Liu et al., 2007).
Additionally, the ability to analyze vast numbers of genomes allows probable metabolic functions to be determined [22].
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The finding suggests that exomeres target the liver to "reprogram" its metabolic function to favor tumor progression.
The heavy demands ofa description of regulatory processes from this viewpoint have led researchers away towards simpler mathematical frameworks in which key experimental measurements are combined with heuristic concepts of metabolic function to make predictions of metabolic fluxes.
Increase in soil bacteria and fungi creates microbial metabolic function to improve the soil biological characteristics [21].
Direct analysis of venom nucleoside levels would be required to determine what level of mRNA expression corresponds to a departure from metabolic function to envenomation.
Furthermore, regulative mechanisms become effective in ectotherms, like the induction of specific heat shock proteins helping to adjust the metabolic functioning to seasonal warming [ 3].
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