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Once candidate ORFs were identified for the metabolic functions, the reliability of the functional assignments was assessed and the ORFs were classified into different categories, according to several criteria, as shown in Fig. 3 and Table 6, and described in the following.
Copper is incorporated into a variety of proteins and metallo-enzymes which perform essential metabolic functions; the micronutrient is necessary for the proper growth, development and maintenance of bone, connective tissue, brain, heart and many other body organs.
In addition to its metabolic functions, the insulin receptor is also capable of stimulating cancer cell proliferation and metastasis.
But when assigning gene contributions for individual metabolic functions, the picture arising from single-perturbations is severely lacking and a multiple-perturbations approach turns out to be essential.
We investigated the ability of the two liver models to carry out these hepatic metabolic functions; the details of each metabolic function simulation are described in Methods.
In order to visualize the retention, loss or gain of higher level metabolic functions, the fraction of enzymes mapped to these pathways is indicated as a pie chart for hypothetical ancestors of selected apicomplexan groups and chromerids.
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Although surgical removal of liver tissue (partial hepatectomy) results in rapid compensatory up-regulation of metabolic function, the liver's innate immune capacity is markedly impaired.
In addition, ghrelin improves both the metabolic functions and the disturbed energy metabolism in the cardiac muscle of obese diabetic rats [ 39].
Viable cells make use of the respiratory and metabolic functions of the cell, the analyte to be monitored being either a substrate or an inhibitor of these processes.
Another area in need of standardization is the assessment of the metabolic functions of the liver tissue or cells in relation to in vivo values.
The hepatocyte is the most metabolically active and performs the most metabolic functions of the three cell types.
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