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The MLST approach, by indexing the nucleotide sequence variation present at several housekeeping loci (which evolve slowly because they are under stabilizing selection for conservation of metabolic function), provides data that are highly discriminatory but enable the population structure of an organism to be established.
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Therefore the analysis allows to assess the presence or absence of certain enzymes in terms of metabolic function, providing stronger criteria to judge erroneous annotation or reliability of the associated CLOGs.
Focusing on LGT in energy-related metabolic pathways considered relevant to EBPR function provides context to the role of LGT in EBPR communities.
Normal thyroid function provides a physiologic hormonal balance, adaptive to changes in metabolic and psychological states.
Thus, while a larger network has a temporarily reduced capacity to accurately predict gene deletion phenotypes, it captures a more complete picture of currently known metabolic functions and provides a framework for network expansion as new pathways are elucidated [ 48].
The intestinal microflora exerts an impact on the nutritional and health status of the host via modulation of the immune and metabolic functions and provides additional enzymatic activities involved in the transformation of dietary compounds [ 16].
DOI: http://dx.doi.org/10.7554/eLife.03613.010 Down-regulated genes showed significant enrichment for terms associated with liver metabolic functions and provide insight to the observed phenotype.
However, it also has a primary role in the response to nutrient deprivation as it sustains metabolic functions by providing energy and metabolites to the cells.
Finally, by relating different sets of enzymes in different species to a common metabolic function, this work provides an infrastructure in which regulatory factors can be incorporated, and functional hypotheses can be generated.
Because lac is upregulated as a compensatory response to mitochondrial impairment, we propose that J-resolved MRS of lac is a noninvasive, surrogate biomarker of impaired metabolic function and would provide a useful means of tracking mitochondrial function during therapeutic trials targeting brain metabolism.
Given the remarkable difference among the different experimental groups, data will be first discussed separately and then a general perspective on social modulation of metabolic functions will be provided.
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