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Because PARP inhibitors enhance oxidative metabolism and improve metabolic flexibility, these compounds are being tested in phase III trials as anti-cancer agents [6, 86].
Improvement of myocardial metabolic flexibility may be achieved by shifting myocardial substrate metabolism to glucose metabolism.
In either case, the results demonstrate that this A. nidulans strain has a high degree of metabolic flexibility with respect to fluxes in the central carbon metabolism.
This metabolic flexibility has endowed it with the ability to adjust metabolism and nutrient uptake to fit the encountered environment (MacCabe 2003).
That capacity lends the animals significant metabolic flexibility and improves the performance of their brains.
Adult stem cells demonstrate metabolic flexibility that is regulated by cell adhesion status.
We hypothesize that prebiotic supplementation with inulin will improve insulin sensitivity and skeletal muscle metabolic flexibility.
PDKs allow metabolic flexibility [69] and are transcriptionally regulated by insulin, glucocorticoids, thyroid hormone and fatty acids [70].
Metabolic variants were clearly discriminated while pathways that support metabolic flexibility towards modulation of a single enzyme were elucidating.
The mechanisms responsible for this metabolic flexibility are unknown.
Utilization of pyrophosphate instead of ATP also adds metabolic flexibility, because reactions become reversible.
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