Impaired adipose tissue angiogenesis could potentially limit adipogenesis and thereby contribute to metabolic dysfunction by promoting ectopic lipid accumulation [ 6].
In their recent work Kong et al. described its regulatory role in adiposity and metabolic dysfunction by enhancing adipose inflammation and stimulating adipocyte proliferation [ 39].
Our findings suggest that age and SD cooperate to induce chronic ER stress that could lead to the death or dysfunction of β-cells, and ultimately exacerbate metabolic dysfunction by compromising insulin secretion.
It remains to be seen whether preventing metabolic dysfunction by treatments like this will further potentiate the beneficial effects of rapamycin in cancer treatment and prevention or longevity extension.
ROS may be produced in a regulated manner during cellular metabolism but they can also arise in an unregulated manner by metabolic dysfunctions and by exogenous stresses.
In addition to Down syndrome, similar mitochondrial and metabolic dysfunctions are accompanied by sensitivity to oxidant stresses in ataxia-telangiectasia, Fanconi anemia, and Werner syndrome [106].
Our findings support a model where aging is composed of two consecutive phases, a first phase characterized by a growing likelihood of displaying intestinal barrier failure/inflammation/systemic metabolic dysfunction followed by a second phase leading to death.
In type 2 diabetic patients, it is possible that breast cancer metastasis may also be augmented by metabolic dysfunctions; thus we investigated in a mouse model whether hyperinsulinemia, specifically, affects the metastasis of primary mammary tumors to the lung.
The aim of this article is to present a critical appraisal of methodological aspects of the article "Resting heart rate: its correlations and potential for screening metabolic dysfunctions in adolescents" presented by BMC Pediatrics.
April 1793 Longbenton, England June 29 , 1860Bristol, Gloucestershire Thomas Addison, (born April 1793, Longbenton, Northumberland, Eng. died June 29 , 1860 Bristol, Gloucestershire) English physician after whom Addison's disease, a metabolic dysfunction caused by atrophy of the adrenal cortex, and Addison's (pernicious) anemia were named.
