Sentence examples for metabolic dysfunction through from inspiring English sources

Adipose tissue (AT) contributes to metabolic dysfunction through imbalanced production of adipokines, including cytokines.

Previous data revealed accumulating fat depots in skeletal muscle in older subjects, leading to metabolic dysfunction through lipotoxicity and to insulin resistance (Petersen et al., 2003; Zoico et al., 2010).

Conclusions: Our findings suggest that HBCD may contribute to enhancement of diet-induced body weight gain and metabolic dysfunction through disruption of lipid and glucose homeostasis, resulting in accelerated progression of obesity.

In the present study we investigated whether exposure to HBCD induces and/or enhances obesity and obesity-related metabolic dysfunction through disruption of lipid and glucose homeostasis in the liver and adipose tissue in HFD-fed and ND-fed mice.

Here we show that isocaloric IF improves metabolic homeostasis against diet-induced obesity and metabolic dysfunction primarily through adipose thermogenesis in mice.

Based on the developmental origins of the health and disease hypothesis or fetal programming (4), the intrauterine environment represents a time when changes in maternal metabolism may affect distant metabolic dysfunction in the offspring mediated through physiological and/or epigenetic mechanisms.

In patients with clinically manifest vascular disease, EV-cystatin C positively relates to metabolic complications of obesity, and may thus contribute to an increased cardiovascular risk through obesity associated metabolic dysfunction.

Recent findings suggest that the environmental component in the development of metabolic dysfunction is mediated, at least in part, through an altered gut microbial structure and function.

Glutamine (Gln), a non-essential amino acid, has been demonstrated to attenuate pro-inflammatory cytokine release [ 13] and lung metabolic dysfunction in animal models of endotoxin shock through enhanced HSP expression [ 14].

Energy metabolic dysfunction can promote the establishment of a hypoxic microenvironment, particularly through abnormal mitochondrial aerobic respiration and increased rate of glycolysis.

Thus, we conclude that metformin acts in part through a B. fragilis GUDCA intestinal FXR axis to improve metabolic dysfunction, including hyperglycemia.