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To understand how mitochondrial metabolic dysfunction contributes to these diseases, a metabolic model of a human heart mitochondrion was created.
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Novel markers may help to elucidate aspects of metabolic dysfunction contributing to diabetes risk and improve the early identification of individuals who might benefit from preventive therapies for diabetes.
This study was designed to determine how metabolic dysfunction might contribute to cognitive impairment and to reveal specific metabolic co-morbidities that could be targeted to preserve brain function.
These age-associated metabolic dysfunctions further contribute to fragility of otherwise healthy older cells and organs, exacerbating the ageing process.
Mitochondrial damage and dysfunction contributes to metabolic shifts and may represent a biological effect along the pathway linking PM to effects on the newborn.
Adipose tissue is an active endocrine and immune organ whose dysfunction contributes to metabolic diseases (e.g., diabetes) and increases cardiovascular disease (22).
Adipose tissue (AT) contributes to metabolic dysfunction through imbalanced production of adipokines, including cytokines.
Thus, we speculate that the loss of glycolytic muscle, which occurs upon aging, leads to an 'energy expenditure deficiency' that contributes to metabolic dysfunction.
In the figure, we emphasize that energy metabolic dysfunction can directly or indirectly contribute to cancers as a carcinogenic factor, probably by affecting the microenvironment.
Growth hormone (GH) inhibits fat accumulation and promotes protein accretion, therefore the fall in GH observed with weight gain and normal aging may contribute to metabolic dysfunction.
Altogether, the results suggest that mitochondrial defects and oxidative stress could contribute to metabolic dysfunction in the aged.
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CEO of Professional Science Editing for Scientists @ prosciediting.com