In addition to the adverse CV effects discussed above, there is increasing evidence that the treatment with antipsychotics may be associated with metabolic disturbances such as impaired glucose metabolism, hyperlipidemia, and weight gain, all of which may adversely affect QOL (Lee et al 2004; Jones et al 2006).
The primary focus of our laboratory is the link between metabolic disturbances, such as obesity and insulin resistance, and the development of subclinical and clinical cardiovascular disease.
Current Research and Scholarly InterestsWe are interested in the link between metabolic disturbances, such as obesity and insulin resistance, and the development of cardiovascular disease.
In China, NAFLD is becoming a greater health concern, with increasing rates of metabolic disturbances, such as obesity, type 2 diabetes mellitus, and dyslipidemia.
Furthermore, some toxins are thought to play a role in metabolic disturbances such as insulin resistance, obesity, and Type 2 diabetes, which is why these disrupting substances are even referred to as "obesogens" (2).
Excessive weight/obesity is also currently seen as a risk factor for cardiovascular disease, and it could, at least in some cases, act as a cause for metabolic disturbances such as hyperglycemia [10].
Nine studies reported the indications for CRRT treatment, including acute renal failure or AKI[1617, 17, 22, 24, 27], FO [ 14- 19, 19, 27, 29] and metabolic disturbance such as hyperkalemia, electrolyte disturbances or azotemia [ 14- 16, 29].
Specifically, there was no history consistent with hereditary interstitial nephritis, no alternative toxic exposure such as to lithium or heavy metals, no metabolic disturbance such as hypokalaemia, hyperuricaemia or hypercalcaemia, no lymphoproliferative disorder, no infection, no obstruction and no hypertension.
It is associated with numerous metabolic and cardiovascular disturbances such as insulin resistance, type 2 diabetes, hypertension, and dyslipidemia (2– 5).
The effect of metabolic disturbances on sleep, such as hyperinsulinemia or increased circulating levels of proinflammatory cytokines, may be empirically addressed in polysomnographical studies.
In addition to the chronic inflammation in the vessel wall causing vascular endothelial dysfunction, the progression of the disease may be enhanced by persistent systemic infection, low-grade inflammation, and metabolic disturbances of major organs such as liver and adipose tissue (AT).
