The chronic metabolic disorders include, but are not restricted to alterations in the metabolism of major energy molecules - carbohydrates, fats, and proteins [ 3] that usually culminate in complications of diabetes.
Common metabolic disorders include obesity, diabetes, metabolic syndrome, and other chronic diseases, including cardiovascular and neurological diseases, stroke, cancers, immune disorder, and chronic respiratory diseases.
Lipid metabolism plays important roles in several metabolic disorders including diabetes, metabolic syndromes, other systemic diseases like cancers (e.g. lung cancer, prostate cancer, breast cancer, oral cancers etc).
The obesogenic dietary regimen causes a number of metabolic disorders, including alterations in the hindgut microbial metabolism.
Shifts in the composition of gut bacterial populations can alter host metabolism and may contribute to the pathogenesis of metabolic disorders, including obesity.
For example, it is now widely recognized that the circadian clock regulates metabolism, and disruption of the clock leads to metabolic disorders, including obesity and diabetes, although the detailed mechanisms are still being uncovered.
The metabolic syndrome (MetS) is a portfolio of metabolic disorders, including abdominal obesity, increased blood pressure (BP), abnormal glucose metabolism, and dyslipidemia [ 11].
Researchers were also able to use the data to identify genes that regulate cholesterol metabolism, facilitating the discovery of mechanisms by which genes contribute to common metabolic disorders, including obesity, hypertension (high blood pressure), and diabetes.
Disturbing the human microbiome has been "linked to a wide array of diseases and metabolic disorders, including obesity, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and behavioral and metabolic disorders," wrote the paper's authors, Alyson L Yee and Jack A Gilbert.
The causes of frozen shoulder are unknown, but it sometimes appears to be associated with metabolic disorders, including thyroid conditions and diabetes, although some patients may have injured the affected shoulder.
Hence, SLC13A5 may serve as a potential therapeutic target in the treatment of metabolic disorders including non-alcoholic fatty liver disease, obesity and diabetes.
