Sentence examples for metabolic degradation in from inspiring English sources

Because they may escape metabolic degradation in the liver, they are excreted unchanged in the urine.

A major drawback of this compound is its rather fast metabolic degradation in vivo.

Cells were treated with rapamycin (50 ng/ml, Sigma) for 72 h; culture medium was refreshed with new medium supplemented with rapamycin after 72 h to avoid rapamycin concentration decrease (due to metabolic degradation) in longer treatments (96 144 h).

A 10 mg oral dose has a reported absolute bioavailability of 80 100%; elimination from the plasma occurs with terminal half-lives of 5 9 h in young individuals and 11 13 h in the elderly.Two-thirds of the drug undergoes metabolic degradation in the liver (half of which is excreted renally and half via the faecal route); one-third is eliminated renally as unchanged drug.

2-Hydroxy-4-(3′-oxo-3′H-benzofuran-2′-yliden)but-2-enoic 2-Hydroxy-4- 3′-oxo-3′H-benzofuran-2′-yliden but-2-enoiczed from dibenzofuran (DBF) through co-metabolic degradation in a lateral dioxygenation pathway.

Its overall substrate specificity profile, divergent phylogenetic homology, and preliminary pathway analysis suggested potential biological functions for FTT0941c in diverse metabolic degradation pathways in F. tularensis.

Because of their lipophilic nature and resistance to metabolic degradation, PCBs bioaccumulate in animals and biomagnify in the food chain [ 1].

The molecular mechanism underlying this compensatory effect might be related to a decrease in the metabolic degradation of this neurotransmitter in the Nrf2-null mice.

Kinetic analysis of the correlation between absorption clearance and metabolic clearance were performed based on Eq. 1 according to the metabolic inhibition model for absorption (1, 2) shown in Figure 1., where CLovt is overall transport clearance of peptide from the mucosal to the serosal sides, where no metabolic degradation of peptide in intestinal tissue occurs during absorption process.

The inconsistency observed between PCR and Western blot analysis of AR may suggest that stability of AR mRNA or rate of metabolic degradation of AR protein in the prostate of these animals was altered [ 47, 48].

The percentage of HEV RNA positive commercial livers was approximately half that of HEV-positive feces at the time of slaughter, which may be caused by metabolic degradation of the virus in liver tissue or by frequent freezing of livers before they are sold in supermarkets or butcher shops, which may reduce the amount of viral RNA.