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The role of astrocytes in metabolic coupling has been reviewed extensively.
Recently, a similar metabolic coupling has been observed in breast cancer (Pavlides et al. 2009), where it has been suggested that the metabolic dependency is well-suited for the overall growth of tumor cells.
Thus, we believe that parasitic epithelial-stromal metabolic coupling has important implications for cancer diagnosis and therapy, for example, in designing novel metabolic imaging techniques and establishing new targeted therapies.
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While algorithms exist to design metabolic network reduction strategies for aligning these objectives, the biochemical basis of the growth-product coupling has remained unresolved.
Metabolic data, other gait variables related to the mechanical work done and the locomotor/respiratory coupling have also been investigated.
The couple has divorced.
Couples has seen a few.
The couple has since had a daughter.
The couple has since divorced.
If the hydrogen hypothesis has difficulties, then perhaps it is another type of metabolic coupling, even though to date no such alternative has been proposed.
As such, it is perhaps not surprising that tumors may have also developed a form of metabolic coupling, specifically involving tumor-stromal interactions.
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