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An alternative or additional possibility is that diazoxide favorably affects metabolic control by improving insulin sensitivity.
Furthermore, the significant increase of severe hypoglycemia in 2007 2010 correlated with the implementation of stringent goals for metabolic control by the German Diabetes Association.
Reversal of type 2 diabetes to normal metabolic control by either bariatric surgery or hypocaloric diet allows for the time sequence of underlying pathophysiologic mechanisms to be observed.
These agents improve metabolic control by enhancing endogenous prandial insulin secretion and inhibiting glucagon secretion, thereby reducing postprandial glucose excursions (20).
A randomly selected subset from all CGM profiles (n = 766) was independently categorised into groups of 'very good', 'good', 'satisfactory'fair',r', and 'poor' metabolic control, by three diabetes specialists.
In type 2 diabetes DPP-4 inhibitors reduce the breakdown of GLP-1 and improve metabolic control by increasing insulin secretion, improving β-cell function, and decreasing glucagon secretion (9).
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Metabolic control measured by HbA1c did not demonstrate clinically relevant differences to other oral glucose lowering drugs.
Interestingly, metabolic control ignited by leptin is not limited to hypothalamic leptin signaling.
For studies that reported diabetes duration, it averaged 7.5 (4.9) years, whereas metabolic control assessed by HbA1c was 7.49 (0.68) % (Table 3).
In conclusion, the stable metabolic control achieved by ITx restores hypoglycemia awareness in type 1 diabetic subjects.
RBF may reduce the risk of hypoglycemia, improve metabolic control estimated by HbA1c, lower exogenous insulin requirements, and lower the risk of long-term complications (5, 7– 13).
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