In other words, aspen cells responded to salicyl alcohol feeding by producing PGs and CTs in a compensatory rather than additive fashion, raising the possibility that there was a metabolic constraint to phenylpropanoid biosynthesis.
Using flux variability analysis, the model reveals key metabolic constraints related to redox homeostasis in these bacteria.
However, the virtual incorporation of an operating EMCoA pathway in a scenario of phototrophic growth with malate demonstrated that the activation of this pathway could not compensate for RubisCO in a mutant strain if malate is the substrate and that instead metabolic constraints related to precursor synthesis can explain this distinct behavior.
Early lesions often have a limited growth potential due to spatial or metabolic constraints and need additional driver mutations to reach a detectable size.
The existence of different life-history strategies could be related to metabolic constraints.
In solid tumors, cells that are not adapted to metabolic constraints such as hypoxia and GD die by necrosis as 'a reparative cell death' that could promote tumor progression by releasing the tumor-promoting cytokine HMGB1 [1]–[6].
This approach provides a technological framework for the diversification and improvement of microbial strains by long-term adaptation to inescapable metabolic constraints.
Here, we explore how nutrient availability in the tumour microenvironment shapes immune responses and identify areas of intervention to modulate the metabolic constraints placed on immune cells in this setting.
A key aim of systems biology is to uncover the metabolic constraints determining such complex phenotypic changes, which can be understood only when the system is analyzed at a global scale [ 2- 4].
Since vials for mineralization were kept 6 months at 4 °C without carbon sources, this increase could be due to cold conditions and metabolic constraints, which also represent a stress from a microbial point of view.
