Sentence examples for metabolic constraints from inspiring English sources

The multiple metabolic constraints imposed by the cancer cell metabolism in the tumor microenvironment minimize the potential of T cells to mediate effector function.

Metabolic constraints to cell function and survival shape tumor progression and immune cell function.

We also uncover environments that suppress the fitness advantage of larger cells, indicating that cell-size-dependent fitness effects are subject to both biophysical and metabolic constraints.

These models take into account the rate of cell division and death, the mutation rate, the size of the tumor, and the dynamics of tumor growth including density limitations caused by geometric and metabolic constraints.

Analysis of amino acid residue occurrence patterns shows no demonstrable influence on sequence censorship by Escherichia coli tRNA isoacceptor profiles or either overall codon or Class II codon usage patterns, suggesting no metabolic constraints on recombinant p3 synthesis.

One benefit of the research, says marine ecologist Joanie Kleypas of the National Center for Atmospheric Research in Boulder, Colorado, is that understanding metabolic constraints will help in predicting how the habitats will change, providing useful information to fisheries managers, for example.

Intracellular Shigella cells expressed the Pu lamB/cor lacZ reporter at high levels, suggesting that infectious cells endure a considerable metabolic constraint during the invasion process.

During these metabolic or hypoxic stresses, tumor cells must adapt to the potentially lethal effects of metabolic constraint; otherwise, they would undergo cell death [7] [9].

Winter Svalbard ptarmigan cannot run, even though their metabolic cost of locomotion was less, suggesting that there was not a metabolic constraint limiting top speed.

In our view, it is not brain size, but rather absolute number of neurons, that imposes a metabolic constraint upon brain scaling in evolution, as individuals with increasing numbers of neurons must be able to sustain their proportionately larger metabolic requirements to keep their brain functional.

Thymine starvation provides an experimentally convenient means to maintain a metabolic constraint on the structure of the E. coli genome.