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Therefore, in vitro toxicological evaluation should ideally be conducted in cell systems retaining adequate metabolic competency and relevant to the route of exposure.
Positive controls to assess the metabolic competency of the liver S9 fractions were 7-Ethoxycoumarin, Propranolol, and Verapamil (Sigma), which were analyzed in parallel to the article.
Unstable analogs of JMN3-003, JMN5-165 and JMN5-166 (figure S1), returned half lives of 38 and 5 minutes in this assay, respectively, confirming metabolic competency of the S9 fractions used.
Comparative genomic analyses of these strains with F. novicida and F. tularensis isolates have revealed major differences in metabolic competency and putative pathogenic characteristics [ 19, 20].
Colonic inflammation with the presence of IL6 associated with neoplastic tissue can alter metabolic competency of epithelial cells by manipulating CYP2E1 and CYP1B1 expression through transcriptional and epigenetic mechanisms.
Similar(55)
Because of its metabolic versatility and high competency for natural genetic transformation, it is a model organism of choice for genetic and metabolic investigations [ 14- 16].
Given that these impairments are closely related to metabolic and neuropathological changes, our study aimed to investigate the functional competency of brain regions in the visuospatial networks responsible for early clinical symptoms in AD using event-related functional magnetic resonance imaging (fMRI).
Metabolic deficiencies.
"The competency is evolutional".
"It's about competency.
Only competency can.
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