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Exact(3)
DILP6 mutant animals present growth defects without obvious metabolic changes, suggesting that DILP6 might have an exclusive growth function.
Interestingly, telomere dysfunction has also been linked to metabolic changes suggesting an interplay between these two processes (Moslehi et al, 2012).
Interestingly, though acute vascular effects were reported with the HIF-1 α inhibitor PX-478, these appeared to be superceded by metabolic changes, suggesting that the overall therapeutic effect of HIF inhibition with PX-478 was also metabolically derived (Welsh et al, 2004).
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These metabolic changes suggest significant shifts in gene expression and in enzymatic processes.
The fact that only male mutants presented with metabolic changes suggested that rejuvenated olfactory neurogenesis and function entails relevant long-term alterations of glucose and lipid metabolism.
Further external validation is given by comparison with the metabolomic data, where the observations of metabolites are highly consistent with the metabolic changes suggested by the microarray data.
We demonstrate its feasibility and ability to characterise early metabolic changes and suggest that it provides added prognostic information to conventional variables such as SUVmax and TV.
Indeed, metabolic changes, as suggested by the developmental mismatch theory [36], are in "conflict" with an adequate postnatal environment.
34 35 These metabolic changes would suggest significant improvement in the lifestyle conditions; which could not be measured by the given study design.
These transcriptional changes suggest that metabolic pathways central to fatty acid and cholesterol homeostasis are significantly altered in XpdTTD liver, both at young and old age.
The observed changes suggest profound metabolic reprogramming in response to the intra-colonic environment.
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