Sentence examples for metabolic changes leading from inspiring English sources
In this paper we have shown that truncations in the intracellular domain of the GHR that impair STAT5 signaling in particular cause dramatic metabolic changes, leading to obesity, and involving the metabolism of the whole body, as evidenced by their consistency between liver tissue and urine.
RA is associated with metabolic changes leading to loss of muscle mass and strength [24].
Prolonged duration of obesity may result in additional metabolic changes, leading to the development of hyperglycemia and diabetes (10, 32).
This includes various metabolic changes leading to a waste of adipose tissue and skeletal muscle mass related to tumour progression [ 5, 6].
Moreover, patients with chronic heart failure show profound metabolic changes, leading to peripheral abnormalities in addition to an initial cardiac impairment.
Alternatively, Daniels et al. suggested that reduced β-adrenergic responsiveness in diabetes is related to metabolic changes leading to impaired energy conversion, which becomes apparent during physiological challenge [ 34].
Therefore, appropriate biomarkers of these processes should give some clues for the management of early metabolic changes, otherwise leading to stages of permanent and progressive vascular lesions.
Given the universality of NAD, its biosynthesis and the physiological importance of NAD degrading enzymes it seems plausible that mutations affecting NAD metabolic enzymes are likely to introduce harmful changes leading to enzymatic malfunction.
Our RNA-seq data thus identify massive transcriptional changes leading to the activation of key metabolic genes required for adipocyte formation and function.
These aforementioned studies, in agreement with our present study, suggest that altered metabolic parameters in DM may induce cardiac gene expression changes leading to the induction of general mechanisms of cell proliferation and cardiac hypertrophy.
Mild proteotoxic stress likely initiates the changes leading to a decline in the MMP and oxygen consumption, while also triggering changes in cellular metabolic activity.
