These metabolic changes contributed to hepatic TG and cholesterol-ester accumulation.
Indeed metabolic changes contribute to most proliferative disorders, including cancer cell development and proliferation [13], [14].
Whether such metabolic changes contributed to the almond-dependent reductions in intake found in this study is unknown.
Many factors, including local ones (immobilization and bone denervation) and systemic ones (hormonal and metabolic changes), contribute to SCI-induced bone damage.
Whether and to what extent this phenomenon represents a physiologic adaptive mechanism to different metabolic needs, or a subtle metabolic change contributing to the ageing process, remains unclear [ 6].
These changes enhance amyloid-β deposition and sustain the cascade of changes contributing to metabolic and functional impairments in neurons [ 115, 116].
The latter enhance Aβ deposition and sustain the cascade of changes contributing to metabolic and functional impairments of neurons in autism of an unknown etiology and caused by chromosome 15q11.2-q13 duplication.
However, it remains unclear to what extent this and other metabolic changes specifically contribute to transformation.
As the detrimental metabolic changes can contribute to the development of cardiovascular disease, these risk factors should be monitored and treated if necessary.
Our observation that Phx1-mediated metabolic changes eventually contributed to long-term survival by curtailing production of ROS and the subsequent oxidative damage in the stationary phase coincides with previous reports on the damaging effect of ROS on chronological lifespan [ 34].
